GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs10804591 | 1 | rs2811435 | chr3:129339470 | TMCC1 | chr3:129366637-129612403:- | 0.31 | 4.26 | 4.74E-5 | Waist-to-hip ratio adjusted for body mass index |
| THYM | cis | rs10804591 | 1 | rs2811437 | chr3:129339045 | TMCC1 | chr3:129366637-129612403:- | -0.31 | -4.29 | 4.36E-5 | Waist-to-hip ratio adjusted for body mass index |
| THYM | cis | rs1577917 | 1 | rs2812972 | chr6:86669880 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -7.62 | 1.9E-11 | Response to antipsychotic treatment |
| THYM | cis | rs1577917 | 1 | rs2816815 | chr6:86691656 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -7.62 | 1.9E-11 | Response to antipsychotic treatment |
| THYM | cis | rs1577917 | 1 | rs2816821 | chr6:86657084 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -7.62 | 1.9E-11 | Response to antipsychotic treatment |
| THYM | cis | rs2143950 | 1 | rs28365850 | chr14:35591316 | KIAA0391 | chr14:35591776-35786673:+ | 0.34 | 4.33 | 3.71E-5 | Atopic dermatitis |
| THYM | cis | rs2143950 | 1 | rs28365850 | chr14:35591316 | PPP2R3C | chr14:35554679-35591679:- | 0.27 | 4.94 | 3.36E-6 | Atopic dermatitis |
| THYM | cis | rs2836974 | 1 | rs2836974 | chr21:40663181 | PSMG1 | chr21:40547390-40555440:- | -0.37 | -4.57 | 1.49E-5 | Cognitive function |
| THYM | cis | rs2143950 | 1 | rs28399702 | chr14:35625217 | PPP2R3C | chr14:35554679-35591679:- | 0.24 | 4.67 | 1.0E-5 | Atopic dermatitis |
| THYM | cis | rs10935120 | 1 | rs28409322 | chr3:134252385 | ANAPC13 | chr3:134196547-134204865:- | -0.59 | -8.13 | 1.58E-12 | Height |
| THYM | cis | rs10935120 | 1 | rs28409322 | chr3:134252385 | CEP63 | chr3:134204575-134293852:+ | -0.41 | -5.87 | 6.33E-8 | Height |
| THYM | cis | rs8050907 | 1 | rs28505517 | chr16:4608099 | NMRAL1 | chr16:4511696-4526307:- | -0.5 | -5.61 | 1.96E-7 | Obesity-related traits |
| THYM | cis | rs4237643 | 1 | rs2862961 | chr11:43656535 | HSD17B12 | chr11:43702143-43878160:+ | 0.57 | 5.83 | 7.53E-8 | Forced vital capacity |
| THYM | cis | rs4237643 | 1 | rs2862963 | chr11:43640115 | HSD17B12 | chr11:43702143-43878160:+ | 0.57 | 5.83 | 7.53E-8 | Forced vital capacity |
| THYM | cis | rs4237643 | 1 | rs2862996 | chr11:43653833 | HSD17B12 | chr11:43702143-43878160:+ | -0.57 | -5.83 | 7.53E-8 | Forced vital capacity |